PubMed Search for "Keith Choe"
Representative Publications
Wimberly K and Choe KP (2022) An extracellular matrix damage sensor signals through membrane-associated kinase DRL-1 to mediate cytoprotective responses in Caenorhabditis elegans. Genetics 220(3): iyab217
Wu CW, Wimberly K, Pietras A, Dodd W, Atlas MB, Choe KP. (2019) RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress. BMC Biology 17(1):56 14 pages
Fontaine P and Choe KP (2018) The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans. International Journal Parasitology: Drugs and Drug Resistance. 2018 Aug;8(2):312-319
Dodd W, Tang L, Lone JC, Wimberly K, Wu CW, Consalvo C, Wright JE, Pujol N, Choe KP. (2018) A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans. Genetics. 208(4):1467-1482
Wu CW, Wang Y, Choe KP. (2017) F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans. Genetics. 2017 Jun;206(2):859-871
Wu CW, Deonarine A, Przybysz A, Strange K, Choe KP. (2016) The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK. PLoS Genet. 2016 Oct 24;12(10):e1006361
Peddibhotla S, Fontaine P, Leung CK, Maloney P, Hershberger PM, Wang Y, Bousquet MS, Leusch H, Mangravita-Novo A, Pinkerton AB, Smith LH, Malany S, and Choe KP (2015) Discovery of ML358, a selective small molecule inhibitor of the SKN-1 pathway involved in drug detoxification and resistance in nematodes. ACS Chemical Biology 10(8):1871-9
Tang L, Choe KP. (2015) Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways. Mech Ageing Dev. 2015 Jul;149:88-98
Leung CK, Wang Y, Malany S, Deonarine A, Nguyen K, Vasile S, Choe KP (2013) An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. PLoS One. 2013 Apr 29;8(4):e62166
Choe KP, Strange K. (2008) Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Am J Physiol Cell Physiol. 2295(6):C1488-98
Choe KP, Przybysz AJ, Strange K. (2009) The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol. 29(10):2704-15
Representative Publications
Wimberly K and Choe KP (2022) An extracellular matrix damage sensor signals through membrane-associated kinase DRL-1 to mediate cytoprotective responses in Caenorhabditis elegans. Genetics 220(3): iyab217
Wu CW, Wimberly K, Pietras A, Dodd W, Atlas MB, Choe KP. (2019) RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress. BMC Biology 17(1):56 14 pages
Fontaine P and Choe KP (2018) The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans. International Journal Parasitology: Drugs and Drug Resistance. 2018 Aug;8(2):312-319
Dodd W, Tang L, Lone JC, Wimberly K, Wu CW, Consalvo C, Wright JE, Pujol N, Choe KP. (2018) A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans. Genetics. 208(4):1467-1482
Wu CW, Wang Y, Choe KP. (2017) F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans. Genetics. 2017 Jun;206(2):859-871
Wu CW, Deonarine A, Przybysz A, Strange K, Choe KP. (2016) The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK. PLoS Genet. 2016 Oct 24;12(10):e1006361
Peddibhotla S, Fontaine P, Leung CK, Maloney P, Hershberger PM, Wang Y, Bousquet MS, Leusch H, Mangravita-Novo A, Pinkerton AB, Smith LH, Malany S, and Choe KP (2015) Discovery of ML358, a selective small molecule inhibitor of the SKN-1 pathway involved in drug detoxification and resistance in nematodes. ACS Chemical Biology 10(8):1871-9
Tang L, Choe KP. (2015) Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways. Mech Ageing Dev. 2015 Jul;149:88-98
Leung CK, Wang Y, Malany S, Deonarine A, Nguyen K, Vasile S, Choe KP (2013) An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. PLoS One. 2013 Apr 29;8(4):e62166
Choe KP, Strange K. (2008) Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Am J Physiol Cell Physiol. 2295(6):C1488-98
Choe KP, Przybysz AJ, Strange K. (2009) The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol. 29(10):2704-15